|Positive FC detected in||human peripheral blood lymphocytes|
|This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.|
|Sample-dependent, check data in validation data gallery|
65063-1-Ig targets CD44 in FC applications and shows reactivity with Human samples.
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Purified T cells from human lymph nodes|
|Full Name||CD44 molecule (Indian blood group)|
|Calculated molecular weight||742 aa, 82 kDa|
|GenBank accession number||BC004372|
|Gene ID (NCBI)||960|
|Purification Method||Affinity purification|
|Storage Buffer||Borate buffered saline, pH 8.2.|
|Storage Conditions||Store at 2-8°C.|
CD44 is a type I transmembrane glycoprotein expressed on embryonic stem cells and in various levels on other cell types including connective tissues and bone marrow. CD44 expression is also upregulated in subpopulations of cancer cells and is recognized as a molecular marker for cancer stem cells (PMID: 29747682). It is a cell-surface receptor that mediates cell-cell and cell-matrix interactions through its affinity for hyaluronic acid (HA) and possibly also through its affinity for other ligands (PMID: 10694938). Adhesion with HA plays an important role in cell migration, tumor growth and progression. CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis.