Anti-Human CD45RB/RAB Rabbit Recombinant Antibody, PBS Only

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• Anti-Human CD45RB/RAB Rabbit Recombinant Antibody, PBS Only (98531-5-PBS)

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  FC experiment of human peripheral blood leukocyte using 98531-5-RR (same clone as 98531-5-PBS)

  1x10^6 human peripheral blood leukocyte were surface stained with 0.25 ug Anti-Human CD45RB/RAB Rabbit RecAb (98531-5-RR, Clone:242918F3), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) and APC-Conjugated Goat Anti-Rabbit IgG(H+L).Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98531-5-PBS in a different storage buffer formulation.

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  FC experiment of human peripheral blood leukocyte using 98531-5-RR (same clone as 98531-5-PBS)

  1x10^6 human peripheral blood leukocyte were surface stained with 0.25 ug Anti-Human PTPRC/CD45-RB Rabbit RecAb (98531-5-RR, Clone:242918F3) (red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98531-5-PBS in a different storage buffer formulation.

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  FC experiment of Transfected CHO using 98531-5-RR (same clone as 98531-5-PBS)

  1x10^6 untransfected or transfected CHO cells were surface stained with 0.25 ug Anti-Human CD45RB/RAB Rabbit RecAb (98531-5-RR, Clone: 242918F3) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98531-5-PBS in a different storage buffer formulation.

CD45RB/RAB Uni-rAb^® Recombinant Antibody for FC

Cat No. 98531-5-PBS

Clone No.242918F3

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

CD45, CD45RAB, CD45RB, EC:3.1.3.48, GP180

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Product Information

98531-5-PBS targets CD45RB/RAB in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: protein tyrosine phosphatase, receptor type, C
• Calculated Molecular Weight: 147 kDa
• GenBank Accession Number: NM_002838.4
• Gene Symbol: CD45
• Gene ID (NCBI): 5788
• ENSEMBL Gene ID: ENSG00000081237
• RRID: AB_3746158
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P08575-3
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CD45RB and CD45RAB are specific isoforms of CD45, a receptor-type protein tyrosine phosphatase (PTP) found on the surface of all nucleated hematopoietic cells, except mature erythrocytes and platelets. They serve as essential phenotypic markers to distinguish naïve T lymphocytes from antigen-experienced memory/effector T cells. CD45RB and CD45RAB designations refer to specific isoforms of CD45 generated through alternative splicing of three variable exons (4, 5, and 6) in the PTPRC gene. These exons encode extracellular domains A, B, and C, respectively, which contain O-linked glycosylation sites that affect the molecule's size, charge, and ligand-binding properties. This antibody can detect CD45RB (contains exons B only) and CD45RAB (contains both exons A and B), but not CD45RABC (contain all three exons) or CD45RBC (contain exons B and C).