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Anti-Human CD48 Rabbit Recombinant Antibody, PBS Only (98170-1-PBS)

Anti-Human CD48 Rabbit Recombinant Antibody, PBS Only

Name: Anti-Human CD48 Rabbit Recombinant Antibody, PBS Only, 1mg
Brand: Proteintech
SKU: 98170-1-PBS-1MG

CD48 Uni-rAb^® Recombinant Antibody for FC

Cat No. 98170-1-PBS

Clone No. 241389F8

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Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

Synonyms

241389F8, BLAST, BLAST1, B-lymphocyte activation marker BLAST-1, CD48 antigen

Formulation: PBS Only

PBS, Azide

PBS Only

Conjugate: Unconjugated

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FC experiment of human peripheral blood leukocytes using 98170-1-RR (same clone as 98170-1-PBS)
1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD48 Rabbit Recombinant Antibody (98170-1-RR, Clone:241389F8) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98170-1-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
×
1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD48 Rabbit Recombinant Antibody (98170-1-RR, Clone:241389F8) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98170-1-PBS in a different storage buffer formulation.
FC experiment of human peripheral blood leukocytes using 98170-1-RR (same clone as 98170-1-PBS)
1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD48 Rabbit Recombinant Antibody (98170-1-RR, Clone:241389F8) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98170-1-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
×
1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD48 Rabbit Recombinant Antibody (98170-1-RR, Clone:241389F8) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98170-1-PBS in a different storage buffer formulation.
Affinity and Kinetic Characterization of 98170-1-RR
Biolayer interferometry (BLl) kinetic assays of 98170-1-RR against Human CD48 were performed. The affinity constant is 0.383 nM.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Overview

Tested Applications
Product Information

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Product Information

98170-1-PBS targets CD48 in FC applications and shows reactivity with human samples.

Tested Reactivity	human
Host / Isotype	Rabbit / IgG
Class	Recombinant
Type	Antibody
Immunogen	CatNo: Eg1005 Product name: Recombinant Human CD48 protein (His Tag) Source: mammalian cells-derived, pHZ-KIsec-C-6HIS Tag: C-6HIS Domain: 27-220 aa of BC016182 Sequence: QGHLVHMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWDSRKSKYFESKFKGRVRLDPQSGALYISKVQKEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDKRPFPKELQNSVLETTLMPHNYSRCYTCQVSNSVSSKNGTVCLSPPCTLARS Predict reactive species
Full Name	CD48 molecule
Calculated Molecular Weight	43 kDa
GenBank Accession Number	BC016182
Gene Symbol	CD48
Gene ID (NCBI)	962
RRID	AB_3672313
Conjugate	Unconjugated
Form	Liquid
Purification Method	Protein A purification
UNIPROT ID	P09326
Storage Buffer	PBS only, pH 7.3.
Storage Conditions	Store at -80°C.

Background Information

Signaling lymphocytic activation molecule family 2 (SLAMF2, CD48) is an adhesion and costimulatory molecule expressed constitutively on most hematopoietic cells, particularly in antigen-presenting cells (APC). CD48 is expressed on all the hematopoietic cells, both in humans and mice, except for murine neutrophils and long-term HSC. CD48 exists as both a membrane-bound (mCD48) and a soluble (sCD48) form. CD48 can activate T cells, antigen-presenting cells and granulocytes, by binding to CD2 or bacterial FimH, and through cell intrinsic effects. Interactions between CD48 and its high-affinity ligand CD244 are more complex, with both stimulatory and inhibitory outcomes. CD48 expression is increased in autoimmunity and allergy diseases, and anti-CD48 monoclonal antibodies have been shown to attenuate experimental autoimmune encephalomyelitis.