Anti-Human CD49b (AK7) Mouse IgG2a Recombinant Antibody, PBS Only

• 

  FC experiment of human peripheral blood platelets using 65583-1-MR (same clone as 65583-1-PBS)

  1x10^6 human peripheral blood platelets were surface stained with 0.25 ug Anti-Human CD49b (AK7) Mouse IgG2a RecAb (65583-1-MR, Clone: AK7) (red) or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4) (blue), and PE-conjugated Goat Anti-Mouse IgG. Cells were not fixed. This data was developed using the same antibody clone with 65583-1-PBS in a different storage buffer formulation.

CD49b Uni-rAb^® Recombinant Antibody for FC

Cat No. 65583-1-PBS

Clone No.AK7

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

FC

Synonyms

ITGA2, AK7, BR, Collagen receptor, GPIa

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Product Information

65583-1-PBS targets CD49b in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Mouse / IgG2a
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Human platelets

• Full Name: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
• Calculated Molecular Weight: 126 kDa
• GenBank Accession Number: NM_002203
• Gene Symbol: Integrin alpha 2
• Gene ID (NCBI): 3673
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P17301
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CD49b, also known as alpha2 integrin, is a type I transmembrane glycoprotein which forms an adhesion molecule VLA-2 with beta1 integrin. CD49b is a receptor for many (extracellular) matrix and non-matrix molecules (PMID: 23847623). CD49b is expressed on numerous cell types including platelets, activated T cells, B cells, and monocytes. CD49b activation skews NK cell effector function to a phenotype that exhibits elevated IFN-γ production with a concomitant inhibition of motility and cytolytic function (PMID: 32971468, 32762681). The Anti-Human CD49b antibody, clone AK7, is derived from Human platelets.