Anti-Mouse CD6 Rabbit Recombinant Antibody, PBS Only

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  FC experiment of BALB/c mouse splenocytes using 98161-1-RR (same clone as 98161-1-PBS)

  1x10^6 BALB/c mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD6 Rabbit Recombinant Antibody (98161-1-RR, Clone:241471F3) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Human CD3. Cells were not fixed. This data was developed using the same antibody clone with 98161-1-PBS in a different storage buffer formulation.

• 

  FC experiment of BALB/c mouse splenocytes using 98161-1-RR (same clone as 98161-1-PBS)

  1x10^6 BALB/c mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD6 Rabbit Recombinant Antibody (98161-1-RR, Clone:241471F3) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98161-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98161-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98161-1-RR against Mouse CD6 were performed. The affinity constant is 0.658 nM.

CD6 Uni-rAb^TM Recombinant Antibody for FC

Cat No. 98161-1-PBS

Clone No.241471F3

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Synonyms

241471F3, T-cell differentiation antigen CD6

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Product Information

98161-1-PBS targets CD6 in FC applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: CD6 fusion protein Eg1401
• Full Name: CD6 antigen
• Calculated Molecular Weight: 72kDa
• GenBank Accession Number: NM_009852.3
• Gene Symbol: Cd6
• Gene ID (NCBI): 12511
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q61003-1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CD6 is a type I transmembrane glycoprotein that belongs to the scavenger receptor cysteine-rich superfamily (PMID: 21880988). It is composed of an extracellular region, which consists of three tandem SRCR domains, a transmembrane region, and a cytoplasmic tail devoid of intrinsic catalytic activity but harboring several phosphorylatable residues suitable for intracellular signal transduction (PMID: 38139340; 23711376). CD6 is expressed by T cells, medullary thymocytes, a subset of B cells and NK cells, and in some cells of the brain (PMID: 1919444; 21178331). CD6 plays a role in lymphocyte activation, proliferation, and survival processes via interaction with its endogenous ligands.