CoraLite® Plus 488-conjugated CD79b Recombinant monoclonal antibody

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  IF Staining of raji using CL488-84234-5

  Immunofluorescent analysis of (4% PFA) fixed raji cells using CoraLite® Plus 488 CD79b antibody (CL488-84234-5, Clone: 241273B7 ) at dilution of 1:200.

CD79b Uni-rAb^® Recombinant Antibody for IF/ICC

Cat No. CL488-84234-5

Clone No.241273B7

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC

Synonyms

241273B7, B29, B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, Ig beta

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Tested Applications

• Positive IF/ICC detected in: raji cells

Recommended dilution

• Immunofluorescence (IF)/ICC: IF/ICC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

CL488-84234-5 targets CD79b in IF/ICC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Recombinant Protein

• Full Name: CD79b molecule, immunoglobulin-associated beta
• Calculated Molecular Weight: 229 aa, 26 kDa
• Observed Molecular Weight: 32-36 kDa
• GenBank Accession Number: BC032651
• Gene Symbol: CD79B
• Gene ID (NCBI): 974
• Conjugate: CoraLite® Plus 488 Fluorescent Dye
• Excitation/Emission Maxima Wavelengths: 493 nm / 522 nm
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P40259
• Storage Buffer: PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
• Storage Conditions: Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage.

Background Information

CD79 molecule encompasses two transmembrane proteins, CD79a and CD79b, which form a disulfide-linked heterodimer and are members of the immunoglobulin (Ig) gene superfamily (PMID: 2033258; 1375264; 2304550). CD79b molecule (also known as B29, IGB, AGM6, and Igbeta) is expressed almost exclusively on B cells and B-cell neoplasms, influencing antigen internalization and increasing antigen presentation efficiency (PMID: 7552998). CD79b mutation could be a key biomarker for DLBCL disease progression (PMID: 36182550).