|Positive FC detected in||human peripheral blood lymphocytes|
|This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.|
|Sample-dependent, check data in validation data gallery|
65144-1-Ig targets CD8a in WB, IHC, FC applications and shows reactivity with Human samples.
|Cited Reactivity||human, pig|
|Host / Isotype||Mouse / IgG1|
|Full Name||CD8a molecule|
|Calculated molecular weight||235 aa, 26 kDa|
|GenBank accession number||BC025715|
|Gene ID (NCBI)||925|
|Purification Method||Affinity purification|
|Storage Buffer||Phosphate based buffer with 0.09% sodium azide, pH 7.2.|
|Storage Conditions||Store at 2-8°C.|
CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells , on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084).
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