Validation Data Gallery
|Positive WB detected in||HEK-293 cells, THP-1 cells, Jurkat cells, NIH/3T3 cells, HeLa cells, ROS1728 cells, C6 cells, Raw 264.7 cells|
|Positive IF detected in||HeLa cells|
|Western Blot (WB)||WB : 1:5000-1:50000|
|Immunofluorescence (IF)||IF : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
66278-1-Ig targets CDK6 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||CDK6 fusion protein Ag5600|
|Full Name||cyclin-dependent kinase 6|
|Calculated molecular weight||326 aa, 36 kDa|
|Observed molecular weight||36-40 kDa|
|GenBank accession number||BC027989|
|Gene ID (NCBI)||1021|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
CDK6(Cyclin-dependent kinase 6) is involved in initiation and maintenance of cell cycle exit during cell differentiation and it prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types.The molecular weight of CDK6 is 36-40 KDa (PMID: 23563707, 8114739).
Int J Mol Sci
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ACS Pharmacol Transl Sci
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The novel LSD1 inhibitor ZY0511 suppresses diffuse large B-cell lymphoma proliferation by inducing apoptosis and autophagy
circ_ARF3 regulates the pathogenesis of osteosarcoma by sponging miR-1299 to maintain CDK6 expression.
Int J Oncol
GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.