CDKL5 Polyclonal antibody, PBS Only

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• CDKL5 Polyclonal antibody, PBS Only (12973-1-PBS)

• 

  WB analysis using 12973-1-AP (same clone as 12973-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 12973-1-AP (CDKL5 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12973-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 12973-1-AP (same clone as 12973-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 12973-1-AP (CDKL5 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12973-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HepG2 using 12973-1-AP (same clone as 12973-1-PBS)

  HepG2 cells were subjected to SDS PAGE followed by western blot with 12973-1-AP (CDKL5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12973-1-PBS in a different storage buffer formulation.

• 

  IP experiment of mouse brain using 12973-1-AP (same clone as 12973-1-PBS)

  IP result of anti-CDKL5 (IP:12973-1-AP, 4ug; Detection:12973-1-AP 1:300) with mouse brain tissue lysate 3200 ug. This data was developed using the same antibody clone with 12973-1-PBS in a different storage buffer formulation.

CDKL5 Polyclonal Antibody for WB, IP, Indirect ELISA

Cat No. 12973-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, Indirect ELISA

Synonyms

cyclin dependent kinase like 5, Cyclin-dependent kinase-like 5, EC:2.7.11.22, ISSX, Serine/threonine-protein kinase 9

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Product Information

12973-1-PBS targets CDKL5 in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag3531

  Product name: Recombinant human CDKL5 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-301 aa of BC036091

  Sequence: MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQR

• Full Name: cyclin-dependent kinase-like 5
• Calculated Molecular Weight: 1030 aa, 114 kDa
• Observed Molecular Weight: 100-110 kDa
• GenBank Accession Number: BC036091
• Gene Symbol: CDKL5
• Gene ID (NCBI): 6792
• RRID: AB_2877899
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O76039
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Cyclin dependent kinase like 5 (CDKL5) may regulate ciliogenesis and neuronal morphogenesis. It has been reported that CDKL5 is associated with epileptic seizures, severe intellectual disability, and autistic features. The CDKL5 protein is a kinase that regulates key phosphorylation events vital to the development of the complex neuronal network of the brain.