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CFLAR/FLIP Polyclonal antibody, PBS Only

CFLAR/FLIP Polyclonal Antibody for WB, IHC, IF/ICC, IP, ELISA

Cat No. 10394-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, IF/ICC, IP, ELISA

CFLAR, c FLIP, c FLIPL, c FLIPR, c FLIPS

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

10394-1-PBS targets CFLAR/FLIP in WB, IHC, IF/ICC, IP, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen CFLAR/FLIP fusion protein Ag0593 Predict reactive species
Full Name CASP8 and FADD-like apoptosis regulator
Calculated Molecular Weight 52 kDa
Observed Molecular Weight 20-35 kDa, 50-55 kDa
GenBank Accession NumberBC001602
Gene Symbol FLIP
Gene ID (NCBI) 8837
RRIDAB_2081087
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDO15519
Storage Buffer PBS only, pH 7.3.
Storage ConditionsStore at -80°C.

Background Information

CFLAR, also named as CASH, CASP8AP1, CLARP, MRIT, Casper, c-FLIP and I-FLICE, belongs to the peptidase C14A family. It is an apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. CFLAR acts as an inhibitor of TNFRSF6 mediated apoptosis. It can be cleaved to be 2 fragments P43 and P12. P43 is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. CFLAR lacks enzymatic (caspase) activity.

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