Product Information
11388-1-PBS targets CHRNA6 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag1921 Product name: Recombinant human CHRNA6 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-251 aa of BC014456 Sequence: MLTSKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPC Predict reactive species |
| Full Name | cholinergic receptor, nicotinic, alpha 6 |
| Calculated Molecular Weight | 494 aa, 57 kDa |
| Observed Molecular Weight | 57 kDa |
| GenBank Accession Number | BC014456 |
| Gene Symbol | CHRNA6 |
| Gene ID (NCBI) | 8973 |
| RRID | AB_2080683 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q15825 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
CHRNA6 (α6) is an α subunit of neuronal nicotinic acetylcholine receptors (nAChRs), encoded by the CHRNA6 gene on chromosome 8. It assembles into pentameric ligand-gated cation channels permeable to Na⁺ and Ca²⁺, often clustered with CHRNB3. It is restrictively expressed mainly in midbrain dopaminergic neurons, noradrenergic neurons and visual system, modulating nicotine-triggered dopamine release. CHRNA6 polymorphisms link to nicotine and alcohol dependence. It participates in reward circuits and is implicated in Parkinson's disease, serving as a promising target for anti-addiction therapeutics.
