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COPS4 Polyclonal antibody, PBS Only (10464-1-PBS)

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WB analysis of mouse brain using 10464-1-AP (same clone as 10464-1-PBS)
mouse brain tissue were subjected to SDS PAGE followed by western blot with 10464-1-AP (COPS4 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10464-1-PBS in a different storage buffer formulation.
WB analysis of PC-3 using 10464-1-AP (same clone as 10464-1-PBS)
PC-3 cells were subjected to SDS PAGE followed by western blot with 10464-1-AP (COPS4 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10464-1-PBS in a different storage buffer formulation.
IP experiment of PC-3 using 10464-1-AP (same clone as 10464-1-PBS)
IP result of anti-COPS4 (IP:10464-1-AP, 4ug; Detection:10464-1-AP 1:300) with PC-3 cells lysate 1800ug. This data was developed using the same antibody clone with 10464-1-PBS in a different storage buffer formulation.
IHC staining of human placenta using 10464-1-AP (same clone as 10464-1-PBS)
Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 10464-1-AP (COPS4 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10464-1-PBS in a different storage buffer formulation.
IHC staining of human placenta using 10464-1-AP (same clone as 10464-1-PBS)
Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 10464-1-AP (COPS4 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10464-1-PBS in a different storage buffer formulation.

COPS4 Polyclonal antibody, PBS Only

Name: COPS4 Polyclonal antibody, PBS Only
Brand: Proteintech
SKU: 10464-1-PBS

COPS4 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA

Cat No. 10464-1-PBS

Review Product

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IP, Indirect ELISA

Synonyms

COPS, COPS 4, CSN4, JAB1 containing signalosome subunit 4, JAB1-containing signalosome subunit 4

Formulation: PBS Only

PBS, Azide, Glycerol

Conjugate: Unconjugated

Size/Concentration:

-/ -

Freight/Packing: -

Quantity

- +

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Overview

Tested Applications
Product Information

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MSDS SDS

Product Information

10464-1-PBS targets COPS4 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity	human, mouse, rat
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	CatNo: Ag0735 Product name: Recombinant human COPS4 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-250 aa of BC004302 Sequence: MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLF Predict reactive species
Full Name	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
Calculated Molecular Weight	46 kDa
Observed Molecular Weight	40 kDa, 46 kDa
GenBank Accession Number	BC004302
Gene Symbol	COPS4
Gene ID (NCBI)	51138
RRID	AB_2081630
Conjugate	Unconjugated
Form	Liquid
Purification Method	Antigen affinity purification
UNIPROT ID	Q9BT78
Storage Buffer	PBS only, pH 7.3.
Storage Conditions	Store at -80°C.

Background Information

COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an ess ential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. CSN4 gene encodes a component of CSN complex, COP9 signalosome complex subunit 4 (COPS4). The ubiquitin-proteasome system plays a major role in the rhythmic accumulation and turnover of molecular clock components. A recent study in Drosophila indicates that CSN lie in a common pathway leading to light-dependent degradation of clock protein Timeless (TIM).