CPT1C Monoclonal antibody

CPT1C Monoclonal Antibody for IHC, WB,ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

human, pig

Applications

WB, IHC,ELISA

Conjugate

Unconjugated

CloneNo.

5D11B5

Cat no : 66072-1-Ig

Synonyms

CATL1, CPT IC, CPT1 B, CPT1C, CPT1P, CPTI B, CPTIC



Tested Applications

Positive WB detected inHuman brain, tissue
Positive IHC detected inhuman testis tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
Immunohistochemistry (IHC)IHC : 1:20-1:200
Sample-dependent, check data in validation data gallery

Product Information

The immunogen of 66072-1-Ig is CPT1C Fusion Protein expressed in E. coli.

Tested Reactivity human, pig
Cited Reactivity human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen CPT1C fusion protein Ag17963
Full Name carnitine palmitoyltransferase 1C
Calculated molecular weight 792 aa, 90 kDa
Observed molecular weight 82 kDa
GenBank accession numberBC029104
Gene symbol CPT1C
Gene ID (NCBI) 126129
Conjugate Unconjugated
Form Liquid
Purification Method Protein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

CPT1C, also named as CATL1, CPTI-B and B-CPTI, belongs to the carnitine/choline acetyltransferase family. Carnitine palmitoyltransferase (CPT) deficiencies are common disorders of mitochondrial fatty acid oxidation. The CPT system is made up of two separate proteins located in the outer (CPT1) and inner (CPT2) mitochondrial membranes. CPT1C is an active forms of related brain-type carnitine palmitoyltransferase I. CPT1C may be a regulated target of malonyl-CoA that relays the “malonyl-CoA signal” in hypothalamic neurons that express the orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. (PMID: 17018521 ) This antibody can bind the close sequences genes.

Protocols

Product Specific Protocols
WB protocol for CPT1C antibody 66072-1-IgDownload protocol
IHC protocol for CPT1C antibody 66072-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

J Gastrointest Oncol

Enhanced fatty acid oxidation mediated by CPT1C promotes gastric cancer progression.

Authors - Tianyi Chen
  • KD Validated
humanWB

Hepatology

Discovery of a CPS1-deficient HCC subtype with therapeutic potential via integrative genomic and experimental analysis.

Authors - Tong Wu
  • KD Validated