CPT1C Monoclonal antibody

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• CPT1C Monoclonal antibody (66072-1-Ig)

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• KD/KO Validated

CPT1C Monoclonal Antibody for WB, IHC, ELISA

Cat No. 66072-1-Ig Copied!

Clone No. 5D11B5

Publications (10)

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Host / Isotype

Mouse / IgG2b

Reactivity

human, pig and More (2)

Applications

WB, IHC, IF, IP, ELISA

Synonyms

CATL1, CPT IC, CPT1 B, CPT1C, CPT1P, CPTI B, CPTIC

• 

  WB analysis of human brain using 66072-1-Ig

  human brain tissue were subjected to SDS PAGE followed by western blot with 66072-1-Ig (CPT1C antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of human testis using 66072-1-Ig

  Immunohistochemical analysis of paraffin-embedded human testis using 66072-1-Ig(CPT1C antibody) at dilution of 1:50 (under 10x lens).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of human testis using 66072-1-Ig

  Immunohistochemical analysis of paraffin-embedded human testis using 66072-1-Ig(CPT1C antibody) at dilution of 1:50 (under 40x lens).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive WB detected in: Human brain, human brain tissue
• Positive IHC detected in: human testis tissue; Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000
• Immunohistochemistry (IHC): IHC : 1:20-1:200

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

66072-1-Ig targets CPT1C in WB, IHC, IF, IP, ELISA applications and shows reactivity with human, pig samples.

• Tested Reactivity: human, pig
• Cited Reactivity: human, mouse, rat, pig
• Host / Isotype: Mouse / IgG2b
• Class: Monoclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag17963

  Product name: Recombinant human CPT1C protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 442-793 aa of BC029104

  Sequence: SFTLIVFSNGKLGLSVEHSWADCPISGHMWEFTLATECFQLGYSTDGHCKGHPDPTLPQPQRLQWDLPDQIHSSISLALRGAKILSENVDCHVVPFSLFGKSFIRRCHLSSDSFIQIALQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACNFVRAMEDKEKTDPQCLALFRVAVDKHQALLKAAMSGQGVDRHLFALYIVSRFLHLQSPFLTQVHSEQWQLSTSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHGYGVSYIFMGDGMITFHISSKKSSTKTDSHRLGQHIEDALLDVASLFQAGQHFKRRFRGSGKENSRHRCGFLSRQTGASKASMTSTDF

• Full Name: carnitine palmitoyltransferase 1C
• Calculated Molecular Weight: 792 aa, 90 kDa
• Observed Molecular Weight: 82 kDa
• GenBank Accession Number: BC029104
• Gene Symbol: CPT1C
• Gene ID (NCBI): 126129
• RRID: AB_11042325
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q8TCG5
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

CPT1C, also named as CATL1, CPTI-B and B-CPTI, belongs to the carnitine/choline acetyltransferase family. Carnitine palmitoyltransferase (CPT) deficiencies are common disorders of mitochondrial fatty acid oxidation. The CPT system is made up of two separate proteins located in the outer (CPT1) and inner (CPT2) mitochondrial membranes. CPT1C is an active forms of related brain-type carnitine palmitoyltransferase I. CPT1C may be a regulated target of malonyl-CoA that relays the "malonyl-CoA signal" in hypothalamic neurons that express the orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. (PMID: 17018521 ) This antibody can bind the close sequences genes.

Publications

What published studies show

The CPT1C antibody (Cat# 66072-1-Ig) has 10 total citations. These appear in journals including Mol Cancer, Hepatology, Cell Commun Signal, Cancer Metab, Int J Mol Sci, Sci Rep, Acta Biochim Biophys Sin, Epigenetics, J Biochem Mol Toxicol, and J Gastrointest Oncol. Research fields span multiple cancer types (lung, liver, breast, colorectal, gastric), fatty acid oxidation and lipid metabolism, adipogenesis, and cardiovascular disease. Applications include WB, IHC, IF, and IP.

Automatically generated from the 10 publication citations by Able AI.

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
human	WB	Mol Cancer; Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma; Authors - Bing Liu ; KD Validated
human	WB	Hepatology; Discovery of a CPS1-deficient HCC subtype with therapeutic potential via integrative genomic and experimental analysis.; Authors - Tong Wu ; KD Validated
human	WB,IP,IHC,IF	Cell Commun Signal; APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition; Authors - Huihui Zhao
human,mouse	WB,IF	Cancer Metab; MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation.; Authors - Ting Zhang
human	WB	Int J Mol Sci; Cpt1c Downregulation Causes Plasma Membrane Remodelling and Anthracycline Resistance in Breast Cancer; Authors - Helena Muley ; KD Validated
human	IHC	Sci Rep; Combining machine learning and multi-omics analysis to explore the role of CPT1C in colorectal tumor cancer transformation.; Authors - Zhouyue Gu