|Positive WB detected in||Human brain, human brain tissue|
|Positive IHC detected in||human testis tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:1000|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
The immunogen of 66072-1-Ig is CPT1C Fusion Protein expressed in E. coli.
|Tested Reactivity||human, pig|
|Cited Reactivity||human, mouse, rat, pig|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||CPT1C fusion protein Ag17963|
|Full Name||carnitine palmitoyltransferase 1C|
|Calculated molecular weight||792 aa, 90 kDa|
|Observed molecular weight||82 kDa|
|GenBank accession number||BC029104|
|Gene ID (NCBI)||126129|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
CPT1C, also named as CATL1, CPTI-B and B-CPTI, belongs to the carnitine/choline acetyltransferase family. Carnitine palmitoyltransferase (CPT) deficiencies are common disorders of mitochondrial fatty acid oxidation. The CPT system is made up of two separate proteins located in the outer (CPT1) and inner (CPT2) mitochondrial membranes. CPT1C is an active forms of related brain-type carnitine palmitoyltransferase I. CPT1C may be a regulated target of malonyl-CoA that relays the "malonyl-CoA signal" in hypothalamic neurons that express the orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. (PMID: 17018521 ) This antibody can bind the close sequences genes.
Discovery of a CPS1-deficient HCC subtype with therapeutic potential via integrative genomic and experimental analysis.
MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation.
Differential regulatory roles of microRNAs during intramuscular adipogenesis in Chinese Guizhou Congjiang Xiang pigs.
J Biochem Mol Toxicol
Polyphyllin I improves myocardial damage in coronary artery disease via modulating lipid metabolism and myocardial apoptosis
J Gastrointest Oncol
Enhanced fatty acid oxidation mediated by CPT1C promotes gastric cancer progression.
Int J Mol Sci
Cpt1c Downregulation Causes Plasma Membrane Remodelling and Anthracycline Resistance in Breast Cancer