CRHR1 Polyclonal antibody, PBS Only

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• CRHR1 Polyclonal antibody, PBS Only (20967-1-PBS)

• 

  WB analysis of HeLa using 20967-1-AP (same clone as 20967-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 20967-1-AP (CRHR1 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20967-1-PBS in a different storage buffer formulation.

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  WB analysis of SH-SY5Y using 20967-1-AP (same clone as 20967-1-PBS)

  SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 20967-1-AP (CRHR1 Antibody) at dilution of 1:100 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20967-1-PBS in a different storage buffer formulation.

CRHR1 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 20967-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

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Product Information

20967-1-PBS targets CRHR1 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: corticotropin releasing hormone receptor 1
• Calculated Molecular Weight: 48 kDa
• Observed Molecular Weight: 46-55 kDa
• GenBank Accession Number: NM_004382
• Gene Symbol: CRHR1
• Gene ID (NCBI): 1394
• RRID: AB_2878776
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P34998
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Corticotropin-releasing hormone (CRH, also known as Corticotropin-releasing factor, CRF) is a 41 amino acid peptide hormone and a key regulator of the stress response. CRH and the related urocortin peptides (UCN, UCN2 and UCN3) mediate their actions through two mammalian receptor subtypes, CRHR1 and CRHR2 (PMID: 23863939). CRHR1 (also known as CRFR1) exhibits high affinity towards CRH and UCN but low affinity towards UCN2 and no affinity towards UCN3 (PMID: 22684850). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Widely distributed throughout the brain, CRHR1 critically controls behavioral adaptation to stress and is causally linked to emotional disorders (PMID: 21885734). Alternative splicing results in multiple transcript variants encoding distinct isoforms of CRHR1. This antibody raised against a synthesized peptide corresponding to amino acid residues 148-165 of isoform CRF-R1 can only recognize isoform CRF-R1.