CRTC1 Polyclonal antibody

CRTC1 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG


Human, mouse and More (2)





Cat no : 27647-1-AP


CRTC1, KIAA0616, MECT1, TORC 1, TORC1, Transducer of CREB protein 1, WAMTP1

Tested Applications

Positive WB detected inNeuro-2a cells, HeLa cells, HEK-293T cells

Recommended dilution

Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Published Applications

WBSee 2 publications below

Product Information

27647-1-AP targets CRTC1 in WB, ELISA applications and shows reactivity with Human, mouse samples.

Tested Reactivity Human, mouse
Cited Reactivityhuman, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen CRTC1 fusion protein Ag26494
Full Name CREB regulated transcription coactivator 1
Calculated Molecular Weight 67 kDa
Observed Molecular Weight 68-75 kDa
GenBank Accession NumberBC017075
Gene Symbol CRTC1
Gene ID (NCBI) 23373
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

CRTC1, also named as Transducer of CREB protein 1, is a 634 amino acid protein, which belongs to the TORC family. CRTC1 is highly expressed in adult and fetal brain and is low expressed in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. CRTC1 localizes in Cytoplasm when is phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (PubMed:16817901). it translocates to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. CRTC1 as a Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. The calculated molecular weight of CRTC1 is 68 kDa, but the modified protein is about 70-75 kDa.


Product Specific Protocols
WB protocol for CRTC1 antibody 27647-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols




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