CXCR3B-specific Antibody 5 Publications

Mouse Monoclonal| Catalog number: 60065-1-Ig |CloneNo.: 1B2D6

Featured Product KD/KO validated

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
Hela cells, Jurkat cells, RAW 264.7 cells, U-937 cells

Positive IHC detected in:
human tonsillitis tissue, human brain tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgG2b

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
chemokine (C-X-C motif) receptor 3

Calculated molecular weight:
46 kDa

Observed molecular weight:
40 kDa+43 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CXCR3

Synonyms
CD183, CKR L2, CMKAR3, CXC R3, CXCR 3, CXCR3, CXCR3A, CXCR3B, G protein coupled receptor 9, GPR9, IP 10 receptor, IP10 R, Mig R, MigR
Background

CXCR3 (C-X-C chemokine receptor type 3) is a G protein-coupled, seven-transmembrane domain chemokine receptor that is expressed on the surface of a number of cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells (PMID: 16847335). CXCR3 binds and is activated by the three IFN-gamma-inducible chemokines: CXCL9, CXCL10, and CXCL11. Binding of these ligands to CXCR3 has been implicated in regulating T-cell infiltration during inflammation and tissue injury (PMID: 17250586). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms, CXCR3B, mediates the angiostatic activity of CXCR3 ligands and also acts as functional receptor for CXCL4 (PMID:12782716). This monoclonal antibody is specific to CXCR3B.


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