Tested Applications
| Positive IF-P detected in | human tonsillitis tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
APC-84591 targets CXCR6 in IF-P applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | chemokine (C-X-C motif) receptor 6 |
| Calculated Molecular Weight | 39 kDa |
| Observed Molecular Weight | 45 kDa |
| GenBank Accession Number | BC033584 |
| Gene Symbol | CXCR6 |
| Gene ID (NCBI) | 10663 |
| Conjugate | APC Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 650 nm / 660 nm |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | O00574 |
| Storage Buffer | PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
Background Information
CXCR6, or C-X-C chemokine receptor 6, is a G protein-coupled receptor with seven transmembrane domains that belong to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. CXCR6 is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signaling pathway that regulates T lymphocyte migration to various peripheral tissues such as the liver, spleen red pulp, intestine, lungs, and skin. CXCR6 plays a crucial role in immunosurveillance through its interaction with epithelial cells and certain subpopulations of intratumor dendritic cells (DC), particularly DC3, which express CXCL16 at the membrane.
Protocols
| Product Specific Protocols | |
|---|---|
| IF protocol for APC CXCR6 antibody APC-84591 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
