Product Information
86045-2-PBS targets CYP7A1 in applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | CYP7A1 fusion protein Ag12572 Predict reactive species |
Full Name | cytochrome P450, family 7, subfamily A, polypeptide 1 |
Calculated Molecular Weight | 504 aa, 58 kDa |
Observed Molecular Weight | 58 kDa |
GenBank Accession Number | BC101777 |
Gene Symbol | CYP7A1 |
Gene ID (NCBI) | 1581 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P22680 |
Storage Buffer | PBS only, pH 7.3. |
Storage Conditions | Store at -80°C. |
Background Information
CYP7A1 (Cytochrome P450 Family 7 Subfamily A Member 1), is a cholesterol 7alpha-hydroxylase, catalyzing the first and rate-limiting step in the neutral or classic pathway for bile acid biosynthesis. CYP7A1 is a postulated gene modifier of colorectal cancer risk and target for the therapeutic bile acid, ursodeoxycholic acid (UDCA). The CYP7A1 enzyme controls the rate-limiting step of the catabolism of cholesterol into bile acids in the liver.