CYP7A1 Recombinant antibody, PBS Only

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  WB analysis using 86045-2-RR (same clone as 86045-2-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86045-2-RR (CYP7A1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86045-2-PBS in a different storage buffer formulation.

CYP7A1 Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Cat No. 86045-2-PBS

Clone No.250554G10

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

Synonyms

Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase, CP7A, CYP7, CYPVII

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Product Information

86045-2-PBS targets CYP7A1 in applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: CYP7A1 fusion protein Ag12572
• Full Name: cytochrome P450, family 7, subfamily A, polypeptide 1
• Calculated Molecular Weight: 504 aa, 58 kDa
• Observed Molecular Weight: 58 kDa
• GenBank Accession Number: BC101777
• Gene Symbol: CYP7A1
• Gene ID (NCBI): 1581
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P22680
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CYP7A1 (Cytochrome P450 Family 7 Subfamily A Member 1), is a cholesterol 7alpha-hydroxylase, catalyzing the first and rate-limiting step in the neutral or classic pathway for bile acid biosynthesis. CYP7A1 is a postulated gene modifier of colorectal cancer risk and target for the therapeutic bile acid, ursodeoxycholic acid (UDCA). The CYP7A1 enzyme controls the rate-limiting step of the catabolism of cholesterol into bile acids in the liver.