Cleaved Caspase 10/P23 Recombinant monoclonal antibody, PBS Only

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  WB analysis of Jurkat using 85104-3-RR (same clone as 85104-3-PBS)

  Staurosporine treated Jurkat cells were subjected to SDS PAGE followed by western blot with 85104-3-RR (Cleaved Caspase 10/P23 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85104-3-PBS in a different storage buffer formulation.

Cleaved Caspase 10/P23 Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 85104-3-PBS

Clone No.242468G11

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

CASP10, Caspase10, 242468G11, Apoptotic protease Mch 4, Apoptotic protease Mch-4

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Product Information

85104-3-PBS targets Cleaved Caspase 10/P23 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: caspase 10, apoptosis-related cysteine peptidase
• Calculated Molecular Weight: 59 kDa
• Observed Molecular Weight: 23 kDa
• GenBank Accession Number: BC042844
• Gene Symbol: Caspase 10
• Gene ID (NCBI): 843
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q92851
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CASP10(Caspase-10) is also named as MCH4 and belongs to the peptidase C14A family. It is recruited to the CD99 and p55 tumor necrosis factor receptor signaling complexes and promoting CD95 (APO1/Fas) apoptosis. It may also play a critical role in PTK7-knockdown-induced apoptosis, downstream of mitochondria(PMID:21103379). This protein can be Cleavage by granzyme B and autocatalytic activity generate two active subunits. Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A)(PMID:16446975), familial non-Hodgkin lymphoma (NHL)(PMID:12010812) and gastric cancer (GASC)(PMID:11973654). This antibody recognize the cleaved caspase 10.