Product Information
33219-1-PBS targets DEFB132 in IHC, IP, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag37893 Product name: Recombinant human DEFB132 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 23-95 aa of BC137293 Sequence: GGSKCVSNTPGYCRTCCHWGETALFMCNASRKCCISYSFLPKPDLPQLIGNHWQSRRRNTQRKDKKQQTTVTS Predict reactive species |
| Full Name | defensin, beta 132 |
| Observed Molecular Weight | 11 kDa |
| GenBank Accession Number | BC137293 |
| Gene Symbol | DEFB132 |
| Gene ID (NCBI) | 400830 |
| RRID | AB_3742901 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q7Z7B7 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Human DEFB132 (Defensin Beta 132) is a member of the beta-defensin family and functions as a secreted antimicrobial peptide. This protein is highly expressed in epididymal epithelial cells and sperm, regulated by the androgen receptor signaling pathway, and serves as a key effector molecule of innate immunity in the male reproductive tract. DEFB132 exhibits broad-spectrum antimicrobial activity, inhibiting both Gram-negative bacteria such as *Escherichia coli* and Gram-positive bacteria such as *Staphylococcus aureus*, exerting its bactericidal function by disrupting the cell membranes of pathogens. As an inducible immune effector molecule, it plays multiple biological roles in host defense, reproductive health, and metabolic homeostasis.
