Product Information
14054-1-PBS targets DLK/MAP3K12 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag4780 Product name: Recombinant human MAP3K12 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 220-567 aa of BC050050 Sequence: CILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGPQLPSLHESHSYSLYIEKYLYKLYIYTYIYIYAPHNQQKDGAVPAVSQARGRLIP Predict reactive species |
| Full Name | mitogen-activated protein kinase kinase kinase 12 |
| Calculated Molecular Weight | 567 aa, 64 kDa |
| Observed Molecular Weight | 100-110 kDa |
| GenBank Accession Number | BC050050 |
| Gene Symbol | MAP3K12 |
| Gene ID (NCBI) | 7786 |
| RRID | AB_3741851 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q12852 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
MAP3K12, also named as DLK ((dual leucine zipper kinase), is a part of a non-canonical MAPK signaling pathway. It has been reported that MAP3K12 can be activated by APOE through a receptor-mediated mechanism. MAP3K12 enhances the AP-1-mediated transcription of APP via a MAP kinase signal transduction pathway composed of MAP2K7, MAPK1/ERK2 and MAPK3/ERK1. MAP3K12 is required for pancreatic beta-cell proliferation during postnatal development and stress-induced JNK signaling in neurons.(PMID: 28111074, 25341110, 32189007)
