Product Information
27243-1-PBS targets DSCR3 in IP, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag23350 Product name: Recombinant human DSCR3 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-297 aa of BC110655 Sequence: MGTALDIKIKRANKVYHAGEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAFYNSVKPIQIINSTIEMVKPGKFPSGKTEIPFEFPLHLKGNKVLYETYHGVFVNIQYTLRCDMKRSLLAKDLTKTCEFIVHSAPQKGKFTPSPVDFTITPETLQNVKERALLPKFLLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQNIQIADGDVCRGLSVPIYMVFPRLFTCPTLETTNFKVEFEVNIVVLLHPDHLITENFPLKLCRI Predict reactive species |
| Full Name | Down syndrome critical region gene 3 |
| Observed Molecular Weight | 30-33 kDa |
| GenBank Accession Number | BC110655 |
| Gene Symbol | DSCR3 |
| Gene ID (NCBI) | 10311 |
| RRID | AB_3742221 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O14972 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
DSCR3 (Down syndrome critical region protein 3) encodes VPS26C (Vacuolar protein sorting-associated protein 26C), a member of the retriever integral membrane protein recycling pathway. DSCR3 is a component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PMID: 31845315). DSCR3 specifically facilitates the transport of LRP1, but not of LDLR, from the endosomes to the plasma membrane, and hereby controls postprandial TG levels in plasma (PMID: 36353989, 35187626).
