DUSP2 Polyclonal antibody, PBS Only

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• DUSP2 Polyclonal antibody, PBS Only (27327-1-PBS)

• 

  WB analysis of A549 using 27327-1-AP (same clone as 27327-1-PBS)

  A549 cells were subjected to SDS PAGE followed by western blot with 27327-1-AP (DUSP2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27327-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 27327-1-AP (same clone as 27327-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 27327-1-AP (DUSP2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27327-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 27327-1-AP (same clone as 27327-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 27327-1-AP (DUSP2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27327-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

DUSP2 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 27327-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Synonyms

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Product Information

27327-1-PBS targets DUSP2 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag25380

  Product name: Recombinant human DUSP2 protein

  Source: e coli.-derived, PET30a

  Tag: 6*His

  Domain: 1-314 aa of BC007771

  Sequence: MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRARGPPAAVLACLLPDRALRTRLVRGELARAVVLDEGSASVAELRPDSPAHVLLAALLHETRAGPTAVYFLRGGFDGFQGCCPDLCSEAPAPALPPTGDKTSRSDSRAPVYDQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVLCH

• Full Name: dual specificity phosphatase 2
• Calculated Molecular Weight: 34 kDa
• Observed Molecular Weight: 34 kDa
• GenBank Accession Number: BC007771
• Gene Symbol: DUSP2
• Gene ID (NCBI): 1844
• RRID: AB_2880845
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q05923
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

DUSP2 belongs to the sub-family of nuclear specific DUSPs that includes DUSP1, 4 and 5. DUSP2 is highly expressed in immune cells, in particular, of patients with inflammatory arthritis, such as in rheumatoid arthritis (RA), and Dusp2 knockout mice present a significant reduction in inflammatory responses. It has been demonstrated that DUSP2 is a downstream target of the tumor suppressor p53 that is required for the cellular response to oxidative stress. DUSP2 is also involved in transcription factor E2F1-mediated apoptotic signaling. Like other members of the DUSP family, DUSP2 interacts with MAPKs; However, the target protein for its phosphatase activity is controversial.