|Positive WB detected in||NIH/3T3 cells|
|Western Blot (WB)||WB : 1:200-1:1000|
|Sample-dependent, check data in validation data gallery|
12191-1-AP targets Endothelin 1 in WB, IP, IF,ELISA applications and shows reactivity with human samples.
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Endothelin 1 fusion protein Ag2847|
|Full Name||endothelin 1|
|Calculated molecular weight||212 aa, 24 kDa|
|Observed molecular weight||24 kDa|
|GenBank accession number||BC009720|
|Gene ID (NCBI)||1906|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
EDN1, also named as Endothelin-1, PPET1 and ET-1, belongs to the endothelin/sarafotoxin family. Endothelins are endothelium-derived vasoconstrictor peptides. Emerging basic science, and animal and human data all suggest that EDN1 is a potentially important contributor in the pathobiology of fibrosing disorders, including those that affect the lung(PMID:20055532 ).
Blocking mitochondrial cyclophilin D ameliorates TSH-impaired defensive barrier of artery.
Lactoferrin-endothelin-1 axis contributes to the development and invasiveness of triple-negative breast cancer phenotypes.