EDNRB Polyclonal antibody, PBS Only

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• EDNRB Polyclonal antibody, PBS Only (20964-1-PBS)

• 

  WB analysis of HEK-293 using 20964-1-AP (same clone as 20964-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 20964-1-AP (EDNRB antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

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  WB analysis of mouse placenta using 20964-1-AP (same clone as 20964-1-PBS)

  mouse placenta tissue were subjected to SDS PAGE followed by western blot with 20964-1-AP (EDNRB antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human placenta using 20964-1-AP (same clone as 20964-1-PBS)

  human placenta tissue were subjected to SDS PAGE followed by western blot with 20964-1-AP (EDNRB antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human placenta using 20964-1-AP (same clone as 20964-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 20964-1-AP (EDNRB Antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human placenta using 20964-1-AP (same clone as 20964-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 20964-1-AP (EDNRB Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

EDNRB Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 20964-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, Indirect ELISA

Synonyms

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Product Information

20964-1-PBS targets EDNRB in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: endothelin receptor type B
• Calculated Molecular Weight: 50 kDa
• Observed Molecular Weight: 53-60 kDa
• GenBank Accession Number: NM_000115
• Gene Symbol: EDNRB
• Gene ID (NCBI): 1910
• RRID: AB_2878774
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P24530
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

EDNRB (endothelin receptor type B) is a G-protein coupled heptahelical endothelin-1 (EDN1) receptor. EDN1, a known mediator of human myometrial contraction in vitro, belongs to a family of three 21-amino acid isopeptides (PMID:18497345). EDNRB is a 442-residue protein expressed post-natally in many tissues, particularly in the myenteric plexus, mucosal layer, ganglia, and blood vessels of the submucosa of the colon (PMID:11434563). Moreover, Both the EDNRA and EDNRB are expressed in ships and can be bound by EDN1. Still, while EDNRA mediates a constrictive effect, EDNRB is involved in vasorelaxation and functions as a clearance receptor that scavenges circulating EDN1 (PMID:30171849).