Product Information
32115-1-PBS targets EFCAB4A in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag37031 Product name: Recombinant human EFCAB4A protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 100-255 aa of BC033196 Sequence: SAQGANPCRTPEETFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGEQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQIREQDLER Predict reactive species |
| Full Name | EF-hand calcium binding domain 4A |
| Observed Molecular Weight | 50 kDa |
| GenBank Accession Number | BC033196 |
| Gene Symbol | EFCAB4A |
| Gene ID (NCBI) | 283229 |
| RRID | AB_3742528 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q8N4Y2 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
EFCAB4A (EF-hand calcium-binding domain-containing protein 4A), also known as CRACR2B (calcium release-activated calcium channel regulator 2B), is a calcium-binding protein containing EF-hand structural domain. EFCAB4A is thought to play a key role in calcium bank-manipulated calcium endocytosis (SOCE) in T cells by regulating activation of CRAC (calcium release-activated calcium channel) channels. This protein may perform a similar function to EFCAB4B, which acts as a cytoplasmic calcium sensor that forms a complex with ORAI1 and STIM1 in the region of the junction between the endoplasmic reticulum and the plasma membrane. The EFCAB4A protein contains two EF-hand structural domains, which may be involved in calcium bank-manipulated calcium endocytosis.
