|Sample-dependent, check data in validation data gallery|
The immunogen of 22542-1-AP is EGFR (N-terminal) Fusion Protein expressed in E. coli.
|Host / Isotype||Rabbit / IgG|
|Immunogen||EGFR (N-terminal) fusion protein Ag16543|
|Full Name||epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)|
|Calculated molecular weight||1210 aa, 134 kDa|
|GenBank accession number||BC094761|
|Gene ID (NCBI)||1956|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
ERBB1, also mamed as EGFR, is a receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. ERBB1 is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin. Isoform 2/truncated isoform of ERBB1 may act as an antagonist. EGFR is associated with lung cancer. The antibody can recognize all the isoforms.
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