ELK1 Polyclonal antibody

• Featured Product
• KD/KO Validated

ELK1 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB,ELISA

Conjugate

Unconjugated

Publications

3

Cat no : 14507-1-AP

Synonyms

ELK1

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Validation Data Gallery

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Recommended dilution

Application	Dilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Published Applications

• KD/KO: See 1 publications below
• WB: See 3 publications below

Product Information

14507-1-AP targets ELK1 in WB,ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: ELK1 fusion protein Ag5966
• Full Name: ELK1, member of ETS oncogene family
• Calculated Molecular Weight: 45 kDa
• GenBank Accession Number: BC056150
• Gene Symbol: ELK1
• Gene ID (NCBI): 2002
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

E twenty-six (ETS)-like transcription factor 1, also known as ELK1, is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. It is targeted in the nucleus by three major MAP kinase pathways as well as the CaMKII pathway. phosphorylation of nuclear Elk1 enhances its ability to bind DNA at serum response elements and stimulate transcription of immediate early genes. Elk1 plays important roles in various contexts, including long-term memory formation, drug addiction, Alzheimer's disease, down syndrome, breast cancer, and depression. This antibody got an 62 kd band in western blotting maybe duo to its phosphorylation

Publications

Species	Application	Title
human	WB	Br J Pharmacol; L-Hcy-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinemia.; Authors - Yi-Ping Leng
human	WB	Gene; Competitive regulation of IPO4 transcription by ELK1 and GABP.; Authors - Pengpeng Xu ; KD Validated
human	WB	Oncol Lett; MicroRNA-326 suppresses the proliferation, migration and invasion of cervical cancer cells by targeting ELK1.; Authors - Ping Zhang