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ERLIN2 Polyclonal antibody, PBS Only (14781-1-PBS)

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WB analysis of HeLa using 14781-1-AP (same clone as 14781-1-PBS)
HeLa cells were subjected to SDS PAGE followed by western blot with 14781-1-AP (ERLIN2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.
WB analysis of HeLa using 14781-1-AP (same clone as 14781-1-PBS)
HeLa cells were subjected to SDS PAGE followed by western blot with 14781-1-AP (ERLIN2 antibody) at dilution of 1:100 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.
IHC staining of human liver cancer using 14781-1-AP (same clone as 14781-1-PBS)
Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 14781-1-AP (ERLIN2 Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.
IHC staining of human liver cancer using 14781-1-AP (same clone as 14781-1-PBS)
Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 14781-1-AP (ERLIN2 Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.

ERLIN2 Polyclonal antibody, PBS Only

ERLIN2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 14781-1-PBS

Review Product

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Synonyms

Formulation: PBS Only

PBS, Azide, Glycerol

Conjugate: Unconjugated

Size/Concentration:

-/ -

Freight/Packing: -

Quantity

- +

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Overview

Tested Applications
Product Information

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MSDS SDS

Product Information

14781-1-PBS targets ERLIN2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity	human, mouse, rat
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	CatNo: Ag6369 Product name: Recombinant human ERLIN2 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 23-206 aa of BC067765 Sequence: VHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGKKVSPEHAVLKQGSWNPASLHCLKPGCLQGVMVTYGQEMLKNLVLRSWSQRSSWRMLIAMQQDP Predict reactive species
Full Name	ER lipid raft associated 2
Calculated Molecular Weight	38 kDa
Observed Molecular Weight	38-45 kDa
GenBank Accession Number	BC067765
Gene Symbol	ERLIN2
Gene ID (NCBI)	11160
RRID	AB_2098859
Conjugate	Unconjugated
Form	Liquid
Purification Method	Antigen affinity purification
UNIPROT ID	O94905
Storage Buffer	PBS only, pH 7.3.
Storage Conditions	Store at -80°C.

Background Information

ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.