ERO1LB Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 18312-1-AP

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Freight/Packing

Con: 67 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, mouse brain tissue, rat brain tissue

Positive IHC detected in:
human pancreas tissue

Recommended dilution:
WB : 1:500-1:3000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
ERO1-like beta (S. cerevisiae)

Calculated molecular weight:
54 kDa

Observed molecular weight:
54kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ERO1LB

Synonyms
ERO1 L beta, ERO1 like beta (S. cerevisiae), ERO1 like protein beta, ERO1LB, Oxidoreductin 1 L beta
Background

ERO1LB is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. It acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Glutathione may be required to regulate its activity in the endoplasmic reticulum. It may be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. It is required for the folding of cell, thereby being a source of oxidative stress. This antibody has no cross reaction to ERO1L.


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