Mouse Endoglin/CD105 Recombinant antibody, PBS Only

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  WB analysis of bEnd.3 using 84807-5-RR (same clone as 84807-5-PBS)

  bEnd.3 cells were subjected to SDS PAGE followed by western blot with 84807-5-RR (Endoglin/CD105 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84807-5-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84807-5-RR

  Biolayer interferometry (BLl) kinetic assays of 84807-5-RR against Mouse Endoglin/CD105 were performed. The affinity constant is 0.766 nM.

Endoglin/CD105 Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Cat No. 84807-5-PBS

Clone No.242305A11

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

WB, Indirect ELISA

Synonyms

CD105, 242305A11, S endoglin, Eng, endoglin

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Product Information

84807-5-PBS targets Endoglin/CD105 in WB, Indirect ELISA applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: endoglin
• Calculated Molecular Weight: 70kDa
• Observed Molecular Weight: 90 kDa
• GenBank Accession Number: NM_007932.2
• Gene Symbol: CD105
• Gene ID (NCBI): 13805
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q63961
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 90-95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)