Product Information
32520-1-PBS targets FANCE in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag38546 Product name: Recombinant human FANCE protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 274-535 aa of NM_021922.2 Sequence: LAESLELPKAIQDQLPRLQQLLKTLEEGLEGLEDAPPVELQLLHECSPSQMDLLCAQLQLPQLSDLGLLRLCTWLLALSPDLSLSNATVLTRSLFLGRILSLTSSASRLLTTALTSFCAKYTYPVCSALLDPVLQAPGTGPAQTELLCCLVKMESLEPDAQVLMLGQILELPWKEETFLVLQSLLERQVEMTPEKFSVLMEKLCKKGLAATTSMAYAKLMLTVMTKYQANITETQRLGLAMALEPNTTFLRKSLKAALKHLGP Predict reactive species |
| Full Name | Fanconi anemia, complementation group E |
| Calculated Molecular Weight | 59 kDa，536aa |
| Observed Molecular Weight | 59 kDa |
| GenBank Accession Number | NM_021922.2 |
| Gene Symbol | FANCE |
| Gene ID (NCBI) | 2178 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q9HB96 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Fanconi anemia group E protein (FANCE) is primarily localized in the nucleoplasm, with additional distribution in mitotic chromosomes and centrosomes. As a key component of the Fanconi anemia (FA) core complex, it plays an essential role in DNA interstrand cross-link repair, serving as a critical bridge between the FA complex and FANCD2 protein (PMID: 12239156; 12093742; 17308347). Cells with FANCE defects exhibit hypersensitivity to DNA cross-linking agents, chromosomal instability, and impaired DNA repair capacity (PMID: 21948210; 28239445; 37563658).
