FCAMR/CD351 Polyclonal antibody, PBS Only

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• FCAMR/CD351 Polyclonal antibody, PBS Only (31929-1-PBS)

FCAMR/CD351 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 31929-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

CD351, Fc Alpha And Mu Receptor, Fc alpha/mu receptor, FCA/MR, Fcalpha/MuR

• 

  WB analysis using 31929-1-AP (same clone as 31929-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31929-1-AP (FCAMR antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31929-1-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  WB analysis using 31929-1-AP (same clone as 31929-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31929-1-AP (FCAMR antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31929-1-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Product Information

31929-1-PBS targets FCAMR/CD351 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag35303

  Product name: Recombinant human FCAMR protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 17-170 aa of NM_001122979.2

  Sequence: LPQKRPHPRWLWEGSLPSRTHLRAMGTLRPSSPLCWREESSFAAPNSLKGSRLVSGEPGGAVTIQCHYAPSSVNRHQRKYWCRLGPPRWICQTIVSTNQYTHHRYRDRVALTDFPQRGLFVVRLSQLSPDDIGCYLCGIGSENNMLFLSMNLTI

• Full Name: Fc receptor, IgA, IgM, high affinity
• Calculated Molecular Weight: 57 kDa
• Observed Molecular Weight: 60 kDa
• GenBank Accession Number: NM_001122979.2
• Gene Symbol: FCAMR
• Gene ID (NCBI): 83953
• RRID: AB_3670149
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q8WWV6
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

FCAMR, also known as CD351 or Fc α/µ receptor, is a type I transmembrane protein. Its extracellular region contains a short extracellular domain (EC) 1, an Ig variable (V) region-like EC2 domain and a stalk-like EC3 domain (PMID: 23182711). FCAMR is present in most B cells and macrophages and is a membrane surface protein that binds to the Fc fragment of IgA and IgM and induces endocytosis (PMID: 11779189). FCAMR may play a role in IgA- and IgM-mediated immune responses to microorganisms (PMID: 11062505).