FcZero-rAb® PE Anti-Human FGFR2/CD332 Rabbit Recombinant Antibody

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• FcZero-rAb® PE Anti-Human FGFR2/CD332 Rabbit Recombinant Antibody (PE-FcA98244)

• Zero Fc receptor binding
• Site-specific conjugation
• One universal isotype

FGFR2/CD332 FcZero-rAb^® Recombinant Antibody for FC

Cat No. PE-FcA98244

Clone No.241383D11

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

FGFR2, BEK, BFR 1, CD332, CEK3

• 

  FC experiment of Transfected HEK-293T using PE-FcA98244

  1x10^6 HEK-293T cells or FGFR2/CD332 transfected HEK-293T cells were surface stained with 5 ul PE Anti-Human FGFR2/CD332 Rabbit RecAb (PE-FcA98244, Clone: 241383D11). Cells were not fixed.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  FC experiment of Transfected HEK-293T using PE-FcA98244

  1x10^6 HEK-293T cells or FGFR2/CD332 transfected HEK-293T cells were surface stained with 5 ul PE Anti-Human FGFR2/CD332 Rabbit RecAb (PE-FcA98244, Clone: 241383D11) (red) or FcZero-rAb® PE Rabbit IgG Isotype Control Recombinant Antibody (PE-FcA98136, Clone: 240953C9) (blue). Cells were not fixed.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive FC detected in: Transfected HEK-293T cells

Recommended dilution

• Flow Cytometry (FC): FC : 5 ul per 10^6 cells in a 100 µl suspension

This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.

Sample-dependent, Check data in validation data gallery.

Product Information

PE-FcA98244 targets FGFR2/CD332 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg1265

  Product name: Recombinant Human FGFR2(IIIc) protein (His Tag)

  Source: mammalian cells-derived, pHZ-KIsec-C-6*HIS

  Tag: C-6*HIS

  Domain: 22-377 aa of NM_000141.4

  Sequence: RPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLE

• Full Name: fibroblast growth factor receptor 2
• Calculated Molecular Weight: 92kd
• GenBank Accession Number: NM_000141.4
• Gene Symbol: FGFR2
• Gene ID (NCBI): 2263
• Conjugate: PE Fluorescent Dye
• Excitation/Emission Maxima Wavelengths: 496 nm, 565 nm / 578 nm
• Excitation Laser: Blue Laser (488 nm), Green Laser (532 nm), Yellow-Green Laser (561 nm)
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P21802
• Storage Buffer: PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3.
• Storage Conditions: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Background Information

FGFR2 (Fibroblast growth factor receptor 2), also known as CD332, is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration, and apoptosis. Ligand binding leads to the activation of several signaling pathways, such as RAS, MAPK1/ERK2, MAPK3/ERK1, and the MAP Kinase signaling pathway, as well as the AKT1 signaling pathway. Mutations in the gene of FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.