ChromoTek FITC Plus-conjugated TIGIT VHH
FITC-tgt targets TIGIT in FC and IF applications and shows reactivity with Human samples.
Host/Type
Alpaca VHH
Reactivity
Human
Applications
FC, IF
Conjugate
FITC Plus Fluorescent dye
Cat no : FITC-tgt
Synonyms
Validation Data Gallery
Product Information
FITC-tgt targets TIGIT in FC and IF applications and shows reactivity with Human samples.
Applications | FC, IF |
Reactivity | Human |
Conjugate | FITC Plus Fluorescent dye |
Type | Nanobody |
Class | Recombinant |
Host | Alpaca |
Affinity | Picomolar range, below the assay limit (biolayer interferometry) |
Molecular Weight | 14.346 kDa |
Form | Liquid |
Excitation/Emission Maxima Wavelengths | 495 nm / 524 nm |
RRID | AB_3101927 |
Storage Buffer | 500 mM NaCl, 10 mM HEPES pH 7.0, 5 mM EDTA, 0.09% sodium azide |
Storage Condition | Store at -20°C; Shipped at ambient temperature. |
Background | TIGIT (T-cell immunoreceptor with Ig and ITIM domains), also known as VSIG9 or VSTM3, is an immune receptor expressed on T cells, including Treg and memory subsets, as well as on NK cells (PMID: 19011627). It contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT binds to poliovirus receptor (PVR, also called CD155) with high affinity, and also to PVRL2 (CD112) with lower affinity. The interaction of TIGIT with PVR on dendritic cells increases the secretion of IL-10 and decreases the secretion of proinflammatory cytokine and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. TIGIT can inhibit NK cytotoxicity directly through its ITIM (PMID: 19815499). |
Documentation
SDS |
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SDS-Immuno-Oncology VHHs |