FRK Polyclonal antibody, PBS Only

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• FRK Polyclonal antibody, PBS Only (16197-1-PBS)

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  WB analysis using 16197-1-AP (same clone as 16197-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16197-1-AP (FRK antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16197-1-PBS in a different storage buffer formulation.

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  IF Staining of HepG2 using 16197-1-AP (same clone as 16197-1-PBS)

  Immunofluorescent analysis of HepG2 cells, using FRK antibody 16197-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). This data was developed using the same antibody clone with 16197-1-PBS in a different storage buffer formulation.

FRK Polyclonal Antibody for WB, IF/ICC, Indirect ELISA

Cat No. 16197-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF/ICC, Indirect ELISA

Synonyms

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Product Information

16197-1-PBS targets FRK in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag10372

  Product name: Recombinant human FRK protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 235-505 aa of BC012916

  Sequence: QLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR

• Full Name: fyn-related kinase
• Calculated Molecular Weight: 505 aa, 56 kDa
• Observed Molecular Weight: 54-57 kDa
• GenBank Accession Number: BC012916
• Gene Symbol: FRK
• Gene ID (NCBI): 2444
• RRID: AB_10639525
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P42685
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

The fyn-related kinase (FRK) belongs to the tyrosine kinase family of protein kinases and is also named PTK5 (protein-tyrosine kinase 5), RAK(Nuclear tyrosine protein kinase). The Frk is a tyrosine kinase expressed in various tissues, such as the gastrointestinal tract and pancreatic islet cells. It affects pancreatic beta cell number during embryogenesis and promotes beta cell cytotoxic signals in response to streptozotocin(PMID:20157399). It may function as a tumor suppressor(PMID:19345329).