FcRn-Specific Polyclonal antibody, PBS Only

• Home
• Products
• Primary Antibodies
• FcRn-Specific Polyclonal antibody, PBS Only (16190-1-PBS)

• 

  WB analysis using 16190-1-AP (same clone as 16190-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16190-1-AP (FcRn-Specific antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

• 

  WB analysis of THP-1 using 16190-1-AP (same clone as 16190-1-PBS)

  WB result of FcRn-Specific antibody (16190-1-AP; 1:600; incubated at room temperature for 1.5 hours) with sh-Control and sh-FcRn-Specific transfected THP-1 cells. This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human spleen using 16190-1-AP (same clone as 16190-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 16190-1-AP (FcRn-Specific antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human spleen using 16190-1-AP (same clone as 16190-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 16190-1-AP (FcRn-Specific antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 16190-1-AP (same clone as 16190-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 16190-1-AP (FcRn-Specific antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

FcRn-Specific Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 16190-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Synonyms

FCGRT, FCRN, Neonatal Fc receptor

---

Product Information

16190-1-PBS targets FcRn-Specific in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: Fc fragment of IgG, receptor, transporter, alpha
• Calculated Molecular Weight: 40 kDa
• Observed Molecular Weight: 40 kDa
• GenBank Accession Number: NM_004107
• Gene Symbol: FcRn
• Gene ID (NCBI): 2217
• RRID: AB_2231751
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P55899
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

The neonatal Fc receptor for IgG (FcRn) is a membrane-associated receptor which acts as a key determinant of IgG homeostasis. FcRn is similar in structure to major histocompatibility class I molecules. It is a heterodimer composed of a alpha chain associated with β2-microglobulin. FcRn transfers IgG from the mother to the fetus across the placenta and the proximal small intestine. In addition, throughout life, FcRn protects IgG from degradation and thus regulates the serum half-life of IgG (PMID: 17703228).