GABA B receptor 1 Polyclonal antibody, PBS Only

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• GABA B receptor 1 Polyclonal antibody, PBS Only (13940-1-PBS)

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  WB analysis using 13940-1-AP (same clone as 13940-1-PBS)

  Boiled and 37°C incubated mouse brain tissue were subjected to SDS PAGE followed by western blot with 13940-1-AP (GABA B receptor 1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13940-1-PBS in a different storage buffer formulation.

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  IHC staining of rat brain using 13940-1-AP (same clone as 13940-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 13940-1-AP (GABA B receptor 1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13940-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse brain using 13940-1-AP (same clone as 13940-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 13940-1-AP (GABA B receptor 1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13940-1-PBS in a different storage buffer formulation.

GABA B receptor 1 Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 13940-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Synonyms

GABAB receptor 1, GABBR1, GABA B R1, GABA BR1, GABA-B receptor 1

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Product Information

13940-1-PBS targets GABA B receptor 1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag4838

  Product name: Recombinant human GABBR1 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 101-471 aa of BC041332

  Sequence: SKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLS

• Full Name: gamma-aminobutyric acid (GABA) B receptor, 1
• Calculated Molecular Weight: 961 aa, 108 kDa
• Observed Molecular Weight: 105-130 kDa
• GenBank Accession Number: BC041332
• Gene Symbol: GABBR1
• Gene ID (NCBI): 2550
• RRID: AB_2108159
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9UBS5
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

GABA B receptor 1 (GABBR1) is an essential protein subunit that forms the functional GABA B receptor, a metabotropic receptor for the primary inhibitory neurotransmitter in the central nervous system, gamma-aminobutyric acid (GABA). Unlike the fast-acting ionotropic GABA A receptors, GABA B receptors mediate slow, prolonged inhibitory signaling through G-proteins. Two bands with the apparent molecular weights of 130 and 105 kDa were corresponding to GABAB1a and GABAB1b proteins, were identified in the brain extract and membrane extract of wild-type mice (PMID: 12970075).