Product Information
16415-1-PBS targets GALNT12 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag9571 Product name: Recombinant human GALNT12 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-272 aa of BC013945 Sequence: MAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML Predict reactive species |
| Full Name | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12) |
| Calculated Molecular Weight | 581 aa, 67 kDa |
| Observed Molecular Weight | 67 kDa |
| GenBank Accession Number | BC013945 |
| Gene Symbol | GALNT12 |
| Gene ID (NCBI) | 79695 |
| RRID | AB_3741886 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q8IXK2 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Polypeptide N‑acetylgalactosaminyl transferase 12 (GALNT12) belongs to the uridine diphosphate N‑acetylgalactosamine gene family, which is involved in numerous biological processes of diseases, such as tumor progression. GALNT12 is highly expressed in the digestive tract and it is frequently downregulated in colorectal cancer (CRC) (PMID: 29095867). Genetic knockdown (KD) and knockout (KO) of GALNT12 in U87 MG, a representative GBM cell line with high GALNT12 expression, confirmed that GALNT12 deficiency leads to decreased cell proliferation, migration and invasion (PMID: 35461073).
