GRB2 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 10254-2-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 50 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, C2C12 cells

Positive IHC detected in:
human pancreas cancer tissue

Positive IF detected in:
HEK-293 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
growth factor receptor-bound protein 2

Calculated molecular weight:
25 kDa

Observed molecular weight:
25-28 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GRB2

Synonyms
Adapter protein GRB2, ASH, EGFRBP GRB2, GRB2, Grb3 3, MST084, MSTP084, Protein Ash, SH2/SH3 adapter GRB2
Background

GRB2 (growth factor receptor-bound protein 2) binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. N-SH3 domain of Grb2 was involved in the protein vesicular localization including amyloid-β protein precursor (AβPP). Involvement of GRB2 in Ras-signaling pathway has been reported, recent finding show that GRB2 may also play a complex role in T and B-cell antigen receptor signaling.


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