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Tested Applications
| Positive WB detected in | mouse brain tissue, rat brain tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
87729-1-RR targets GRM5 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | glutamate receptor, metabotropic 5 |
| Calculated Molecular Weight | 132 kDa |
| Observed Molecular Weight | 120 kDa |
| GenBank Accession Number | NM_000842 |
| Gene Symbol | GRM5 |
| Gene ID (NCBI) | 2915 |
| RRID | AB_3745722 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P41594 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
GRM5 (mGluR5) is a group I class C GPCR that couples to Gq/PLCβ signaling to regulate postsynaptic glutamatergic transmission, calcium signaling, and synaptic plasticity. Highly enriched in cortical, hippocampal, and striatal neurons, GRM5 is a key modulator of learning, memory, excitability, and neurobehavioral circuit function. Dysregulation of GRM5 signaling has been implicated in fragile X syndrome, autism-related disorders, neuropsychiatric disease, chronic pain, and neurodegeneration, making it a major target in CNS drug discovery.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for GRM5 antibody 87729-1-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
