GRM5 Recombinant monoclonal antibody, PBS Only

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• GRM5 Recombinant monoclonal antibody, PBS Only (87729-1-PBS)

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  WB analysis using 87729-1-RR (same clone as 87729-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 87729-1-RR (GRM5 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87729-1-PBS in a different storage buffer formulation.

GRM5 Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 87729-1-PBS

Clone No.253103B9

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

GPRC1E, mGlu5, MGLUR5

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Product Information

87729-1-PBS targets GRM5 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: glutamate receptor, metabotropic 5
• Calculated Molecular Weight: 132 kDa
• Observed Molecular Weight: 120 kDa
• GenBank Accession Number: NM_000842
• Gene Symbol: GRM5
• Gene ID (NCBI): 2915
• RRID: AB_3745722
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P41594
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

GRM5 (mGluR5) is a group I class C GPCR that couples to Gq/PLCβ signaling to regulate postsynaptic glutamatergic transmission, calcium signaling, and synaptic plasticity. Highly enriched in cortical, hippocampal, and striatal neurons, GRM5 is a key modulator of learning, memory, excitability, and neurobehavioral circuit function. Dysregulation of GRM5 signaling has been implicated in fragile X syndrome, autism-related disorders, neuropsychiatric disease, chronic pain, and neurodegeneration, making it a major target in CNS drug discovery.