GUCY2D Polyclonal antibody, PBS Only

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• GUCY2D Polyclonal antibody, PBS Only (55127-1-PBS)

• 

  WB analysis of mouse brain using 55127-1-AP (same clone as 55127-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 55127-1-AP (GUCY2D antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55127-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human brain using 55127-1-AP (same clone as 55127-1-PBS)

  human brain tissue were subjected to SDS PAGE followed by western blot with 55127-1-AP (GUCY2D antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55127-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human brain using 55127-1-AP (same clone as 55127-1-PBS)

  human brain tissue were subjected to SDS PAGE followed by western blot with 55127-1-AP (GUCY2D antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55127-1-PBS in a different storage buffer formulation.

GUCY2D Polyclonal Antibody for WB, Indirect ELISA

Cat No. 55127-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

CG-E, CORD5, CORD6, CYGD, EC:4.6.1.2

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Product Information

55127-1-PBS targets GUCY2D in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: guanylate cyclase 2D, membrane (retina-specific)
• Calculated Molecular Weight: 120 kDa
• Observed Molecular Weight: 120 kDa, 95 kDa
• GenBank Accession Number: NM_000180
• Gene Symbol: GUCY2D
• Gene ID (NCBI): 3000
• RRID: AB_10804281
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q02846
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

GUCY2D, also named as CORD6, GUC1A4, GUC2D, RETGC, RETGC1 and ROS-GC, belongs to the adenylyl cyclase class-4/guanylyl cyclase family. It probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. A number of nonsense and frameshift mutations in the GUCY2D gene have been identified in LCA1 patients. Defects in GUCY2D are the cause of cone-rod dystrophy type 6 (CORD6). GUCY2D is responsible for many reported cases of autosomal dominant CRDs. The antibody is specific to GUCY2D.