HCN4 Recombinant antibody, PBS Only

• 

  WB analysis using 85222-4-RR (same clone as 85222-4-PBS)

  Mouse brain tissue lysates were subjected to SDS PAGE followed by western blot with 85222-4-RR (HCN4 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85222-4-PBS in a different storage buffer formulation.

HCN4 {ptg:Brand} Recombinant Antibody for WB, Indirect ELISA

Cat No. 85222-4-PBS

Clone No.242695D11

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Synonyms

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, 242695D11

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Product Information

85222-4-PBS targets HCN4 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Peptide
• Full Name: hyperpolarization activated cyclic nucleotide-gated potassium channel 4
• Calculated Molecular Weight: 129 kDa
• Observed Molecular Weight: 130 kDa
• GenBank Accession Number: NM_005477
• Gene Symbol: HCN4
• Gene ID (NCBI): 10021
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q9Y3Q4
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

HCN4 belongs to the potassium channel HCN family. It hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. HCN4 may contribute to the native pacemaker currents in heart (If) and in neurons (Ih). It is activated by cAMP. HCN4 may mediate responses to sour stimuli. (PMID:10228147). Defects in HCN4 are a cause of sick sinus syndrome type 2 (SSS2). Defects in HCN4 are the cause of Brugada syndrome type 8 (BRS8).