Product Information
33973-1-PBS targets HICE1 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag40571 Product name: Recombinant human HICE1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 118-284 aa of BC010176 Sequence: DVGDSEENVQVLDLLSELKDVTAKKDLELRRSFAQVLELSAEASKEAALANQEVWEETQGMAPPSRWYFNQDSACRESGGAPKNTPLSEDDNPGASSAPAQATFISPSEDFSSSSQAEVPPSLSRSGRDLS Predict reactive species |
| Full Name | HEC1/NDC80 interacting, centrosome associated 1 |
| Calculated Molecular Weight | 410 aa, 45 kDa |
| Observed Molecular Weight | 38kDa, 45kDa |
| GenBank Accession Number | BC010176 |
| Gene Symbol | HICE1 |
| Gene ID (NCBI) | 93323 |
| RRID | AB_3743129 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q9BT25 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
The HICE1 protein (also known as HAUS8) is an important member of the HICE (Hippo pathway components-enriched) family. Hice1 shows distinct cytoplasmic localization and associates with interphase centrosomes and mitotic spindles, preferentially at the spindle pole vicinity. It primarily serves as a core component of the STRIPAK complex (Striatin-interacting phosphatase and kinase complex), where it inhibits the activity of the key kinases MST1/2 in the Hippo signaling pathway by regulating their dephosphorylation, thereby playing a critical role in organ size control, tissue homeostasis maintenance, and cell proliferation and apoptosis.
