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HNRNPA2B1 Monoclonal antibody
HNRNPA2B1 Monoclonal Antibody for IF, IHC, WB, ELISA
Cat no : 67445-1-Ig
|Positive WB detected in||HeLa cells|
|Positive IHC detected in||human colon tissue, human lung cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||U2OS cells|
|Western Blot (WB)||WB : 1:5000-1:50000|
|Immunohistochemistry (IHC)||IHC : 1:8000-1:32000|
|Immunofluorescence (IF)||IF : 1:400-1:1600|
|Sample-dependent, check data in validation data gallery|
67445-1-Ig targets HNRNPA2B1 in WB, IHC, IF, ELISA applications and shows reactivity with Human, mouse, rat samples.
|Tested Reactivity||Human, mouse, rat|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||HNRNPA2B1 fusion protein Ag6699|
|Full Name||heterogeneous nuclear ribonucleoprotein A2/B1|
|Calculated molecular weight||37 kDa|
|Observed molecular weight||36 kDa|
|GenBank accession number||BC000506|
|Gene ID (NCBI)||3181|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Aliquoting is unnecessary for -20oC storage.|
HnRNPA2B1 is one of heterogenous nuclear ribonucleoproteins (HnRNPs), which regulate the splicing and transportation of mRNA and participate in carcinogenesis. It has a role in packaging nascent mRNA, alternative splicing, tycoplamic RNA trafficking, translation and stabilization. Besides it may involve in telomere maintenance, cell proliferation and differentiation, and glucose transport.
Stem Cell Res Ther
Requirement of splicing factor hnRNP A2B1 for tumorigenesis of melanoma stem cells.
HNRNPA2B1 regulates tamoxifen- and fulvestrant-sensitivity and hallmarks of endocrine resistance in breast cancer cells.