Recombinant Human APCS protein (His Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
His Tag
Activity
not tested
Cat no : Eg0528
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human APCS protein His20-Val223 (Accession# P02743 ) with a His tag at the C-terminus. |
| GeneID | 325 |
| Accession | P02743 |
| PredictedSize | 27.7 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Serum Amyloid P component (SAP) is a 25 kDa pentameric protein that plays a crucial role in the humoral arm of innate immunity, involved in resistance to bacterial infection and regulation of inflammation. It is an acute-phase reactant, meaning its levels increase in response to inflammation or infection. SAP is also a key component of amyloid deposits in various amyloidosis disorders, making it a potential therapeutic target for these conditions. Additionally, SAP has been shown to bind to Fcγ receptors and opsonize particles for phagocytosis, highlighting its role in immune defense mechanisms.
References:
1. Wang, Haixia et al. Molecular immunology vol. 172 (2024): 1-8. 2. Doni, Andrea et al. Nature communications vol. 12,1 3739. 18 Jun. 2021. 3. Klotz, Stephen A, and Peter N Lipke. Pathogens (Basel, Switzerland) vol. 11,11 1304. 6 Nov. 2022.