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Recombinant Human APCS protein (His Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

His Tag

Activity

not tested

Cat no : Eg0528

Validation Data Gallery

  • Purity of Recombinant Human APCS was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) condition and stained using Coomassie blue.

    Purity of Recombinant Human APCS was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) condition and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <1.0 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human APCS protein His20-Val223 (Accession# P02743 ) with a His tag at the C-terminus.
GeneID 325
Accession P02743
PredictedSize 27.7 kDa
SDS-PAGE
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Serum Amyloid P component (SAP) is a 25 kDa pentameric protein that plays a crucial role in the humoral arm of innate immunity, involved in resistance to bacterial infection and regulation of inflammation. It is an acute-phase reactant, meaning its levels increase in response to inflammation or infection. SAP is also a key component of amyloid deposits in various amyloidosis disorders, making it a potential therapeutic target for these conditions. Additionally, SAP has been shown to bind to Fcγ receptors and opsonize particles for phagocytosis, highlighting its role in immune defense mechanisms.

References:

1. Wang, Haixia et al. Molecular immunology vol. 172 (2024): 1-8.                                                                                                  2. Doni, Andrea et al. Nature communications vol. 12,1 3739. 18 Jun. 2021.                                                                             3. Klotz, Stephen A, and Peter N Lipke. Pathogens (Basel, Switzerland) vol. 11,11 1304. 6 Nov. 2022.