Recombinant Human B2M protein (mFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

mFc Tag

Activity

not tested

Cat no : Eg2284



Product Information

Purity >90 %, SDS-PAGE
Endotoxin <1.0 EU/μg protein, LAL method
Activity
Not tested
Expression HEK293-derived Human B2M protein Ile21-Met119 (Accession# P61769) with a mouse IgG Fc tag at the C-terminus.
GeneID 567
Accession P61769
PredictedSize 38.4 kDa
SDS-PAGE
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Beta-2-microglobulin (B2M) is an important component of the major histocompatibility complex class I (MHC-I) molecule that is expressed on the surface of almost all nucleated cells. B2M has been suggested as an emerging biomarker for cardiovascular diseases (CVD), including coronary heart disease (CHD) and stroke, and mortality. B2M also complexes with many non-classical MHC-I like molecules such as CD1, MR1, HLA-E, -F, -G and neonatal Fc receptor that are involved in mucosal immunity, tumour surveillance, immunoglobulin and albumin homeostasis.

References:

1. Berggård, I, and A G Bearn. The Journal of biological chemistry vol. 243,15 (1968): 4095-103. 2. Shi, Fanchao et al. Atherosclerosis vol. 320 (2021): 70-78. 3. Argyropoulos, Christos P et al. Frontiers in medicine vol. 4 73.