Recombinant Human B2M protein (mFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
mFc Tag
Activity
not tested
Cat no : Eg2284
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human B2M protein Ile21-Met119 (Accession# P61769) with a mouse IgG Fc tag at the C-terminus. |
| GeneID | 567 |
| Accession | P61769 |
| PredictedSize | 38.4 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Beta-2-microglobulin (B2M) is an important component of the major histocompatibility complex class I (MHC-I) molecule that is expressed on the surface of almost all nucleated cells. B2M has been suggested as an emerging biomarker for cardiovascular diseases (CVD), including coronary heart disease (CHD) and stroke, and mortality. B2M also complexes with many non-classical MHC-I like molecules such as CD1, MR1, HLA-E, -F, -G and neonatal Fc receptor that are involved in mucosal immunity, tumour surveillance, immunoglobulin and albumin homeostasis.
References:
1. Berggård, I, and A G Bearn. The Journal of biological chemistry vol. 243,15 (1968): 4095-103. 2. Shi, Fanchao et al. Atherosclerosis vol. 320 (2021): 70-78. 3. Argyropoulos, Christos P et al. Frontiers in medicine vol. 4 73.