Recombinant Human CD24 protein (rFc Tag)(HPLC verified)

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• Recombinant Human CD24 protein (rFc Tag)(HPLC verified) (Eg1779)

Species

Human

Purity

>90 %, SDS-PAGE
>90 %, SEC-HPLC

Tag

rFc Tag

Activity

not tested

Cat no : Eg1779

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Validation Data Gallery

• 

  Purity of Recombinant Human CD24 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

• 

  The purity of Human CD24 was greater than 90% as determined by SEC-HPLC.

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Product Information

• Purity: >90 %, SDS-PAGE; >90 %, SEC-HPLC
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human CD24 protein Ser27-Gly59 (Accession# P25063-1) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 100133941
• Accession: P25063-1
• PredictedSize: 29.4 kDa
• SDS-PAGE: 38-50 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

CD24 (known as heat stable antigen) is a small highly glycosylated GPI-linked sialoprotein. It is normally expressed at the surface of most B lymphocytes and differentiating neuroblasts, and it is also up-regulated in a wide variety of cancers. Studies have shown that CD24 functions in the regulation of B-cell apoptosis, leukocyte signal transduction, and leukocyte adhesion.

References:

1. T Suzuki, et al. (2001). J Immunol. May 1;166(9).
2. Yang Liu, Pan Zheng. (2023). Front Immunol. May 9:14:1174789.
3. Yang-Hong Ni, et al. (2020). Curr Gene Ther. 20(2):109-126.
4. Peter Altevogt, et al. (2021). Int J Cancer. Feb 1;148(3):546-559.