Recombinant Human CD30 Ligand/TNFSF8 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2118



Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity
Not tested
Expression HEK293-derived Human CD30 Ligand protein Gln63-Asp234 (Accession# P32971) with a rabbit IgG Fc tag at the N-terminus.
GeneID 944
Accession P32971
PredictedSize 46.8 kDa
SDS-PAGE 48-68 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

TNFSF8, also named as CD30LG and CD153, is a member of the tumor necrosis factor (TNF) receptor superfamily. It is the cytokine that binds to TNFRSF8/CD30. It induces proliferation of T-cells. CD30L enhanced the proliferation of CD3-activated T cells, but induced differential responses, including cell death, in several CD30-positive lymphoma-derived cell lines.

References:

1.Ezogelin Oflazoglu, et al. (2009) Adv Exp Med Biol. 647:174-85. 2.Nancy D Marín, et al. (2017) Tuberculosis (Edinb). 102:8-15. 3.Jin Duan, et al. (2019) Int Immunopharmacol. 71:350-360.